Gene Expression Analysis via Spatial Clustering and Evaluation Indexing

Evaluation and optimization of clustering in gene expression data analysis

MOTIVATION A measurement of cluster quality is needed to choose potential clusters of genes that contain biologically relevant patterns of gene expression. This is strongly desirable when a large number of gene expression profiles have to be analyzed and proper clusters of genes need to be identified for further analysis, such as the search for meaningful patterns, identification of gene functi...

Clustering of Leukemia Patients via Gene Expression Data Analysis

Spatial Color Indexing Using Data Clustering Technique

This paper presents an efficient spatial indexing technique for content-based image retrieval. Spatial index is generated based upon a fast and robust clustering technique, which can recognize color clusters of any shape. It also exploits entropy measure to decide whether quantization is needed before clustering. Based on experimentation, the performance of the new indexing technique has been f...

Evaluation and optimization of clustering in gene expression data analysis Journal of Bioinformatics 1 Evaluation and optimization of clustering in gene expression data analysis

Motivation: A measurement of cluster quality is needed to choose potential clusters of genes that contain biologically relevant patterns of gene expressions. This is strongly desirable when large number of gene expression profiles have to be analyzed and proper clusters of genes need to be identified for further analysis, such as the search for meaningful patterns, identification of gene functi...

Unsupervised Clustering Analysis of Gene Expression

The availability of whole genome sequence data has facilitated the development of high-throughput technologies for monitoring biological signals on a genomic scale. The revolutionary microarray technology, first introduced in 1995 (Schena et al., 1995), is now one of the most valuable techniques for global gene expression profiling. Other high-throughput genomic technologies, such as Serial Ana...